Genetic Characterization of the Rotavirus Nonstructural Protein, NSP4
نویسندگان
چکیده
منابع مشابه
Rotavirus Nonstructural Protein 4 (NSP4)-Viral Enterotoxin with Multiple roles in Pathogenesis of Diarrhoea in Children
Article history: Received on: 06/05/2015 Revised on: 24/05/2015 Accepted on: 14/07/2015 Available online: 27/07/2015 Nonstructural protein 4 (NSP4) of Rotavirus has been designated as the first viral enterotoxin. Its role in viral replication is already well known. Intensive research over the past decade has shown the involvement of this protein in many cellular activities both in ‘expressed’ a...
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Abstract Background and Aims: The number of new cancer cases with considerable mortality is increasing worldwide. Since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. Gene therapy has widespread systemic cytotoxic effects against tumor cells. Rotavirus NSP4 has been shown to...
متن کاملRotavirus nonstructural glycoprotein NSP4 is secreted from the apical surfaces of polarized epithelial cells.
NSP4, a nonstructural glycoprotein encoded by rotavirus, is involved in the morphogenesis of virus particles in the endoplasmic reticulum of infected cells. NSP4 is also implicated in the pathophysiology of rotavirus-induced diarrhea by acting as an enterotoxin. To mediate enterotoxic effects in vivo, NSP4 must be secreted or released from rotavirus-infected cells in a soluble form; however, pr...
متن کاملEvaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection.
The immune response elicited by the rotavirus nonstructural protein NSP4 and its potential role in protection against rotavirus disease are not well understood. We investigated the serological response to NSP4 and its correlation with disease protection in sera from 110 children suffering acute diarrhea, associated or not with rotavirus, and from 26 children who were recipients of the rhesus ro...
متن کاملMutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence.
Rotaviruses are major pathogens causing life-threatening dehydrating gastroenteritis in children and animals. One of the nonstructural proteins, NSP4 (encoded by gene 10), is a transmembrane, endoplasmic reticulum-specific glycoprotein. Recently, our laboratory has shown that NSP4 causes diarrhea in 6- to 10-day-old mice by functioning as an enterotoxin. To confirm the role of NSP4 in rotavirus...
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ژورنال
عنوان ژورنال: Virology
سال: 1997
ISSN: 0042-6822
DOI: 10.1006/viro.1997.8727